Gout - a disease that is characterized by impaired metabolism and deposition of uric acid in the internal organs.Especially when this disease affects the kidneys and joints (the big toe is affected most often).Often, sick people who are overweight, do not observe the diet (especially abusers sorrel, tomatoes, legumes, fatty, salty foods, meat, chocolate), alcohol consumption.Also, the development of the disease may provoke uncomfortable wearing tight shoes.How to cure this disease folk remedies.
This disease is manifested even in the elderly (the average age of the beginning of the disease in men 40-45 years, women - 55 years).There are several factors that predispose to the development of gout :
1) the presence of relatives of patients with gout;
2) excess body weight (15%);
3) arterial hypertension;
4) abuse of alcohol.
Approximately 10% of patients with gout is a secondary character and develops against the background of other diseases.In most cases, gout is associated with diabetes.The dise
According to epidemiological studies, gout suffers 0,04-0,37% of the adult population, 90% of them are men.It is believed that the basis of the disease are disorders of activity of enzymes involved in the synthesis of uric acid or its transport system in the kidney tubules.
The development of the disease, there are several stages:
most striking symptom of gout - arthritis (joint inflammation).Getting the disease often manifests (first seen) nephrolithiasis.
often the manifestation of the disease is preceded by prodromal phenomena: the psycho-emotional disorders (depression, euphoria, aggressiveness), dysuria (change in urination frequency, quantity and nature of urine), dyspepsia (indigestion nausea, vomiting, belching, violation of a chair).Manifest night pain in the joints.Gouty attack accompanied by chills, fever, sweating, tachycardia, hypertension.There is extra-articular lesion localization.This may be affected skin, tendons, muscles, tonsils, kidney (dermatitis, tenosynovitis, myositis, tonsillitis, nephropathy, respectively).
chronic stage of the disease is characterized by the formation of arthritic changes in the joints and form kidney involvement in the process.Renal disease is the second most frequent manifestations of gout after the involvement of the joints.Approximately 30% of gout sufferers show signs of kidney disease.
There are two types of lesions in gout.The first type of injury - urate nephropathy - is characterized mainly by the kidney changes, as manifested by the presence of unstable proteins in the urine, leukocytes, hypertension.Nephropathy progresses very slowly, and in 17-25% of patients noted the development of chronic renal failure.
second type - damage to the kidneys and other parts of the urinary system - is characterized by the formation of uric acid stones (bowl with secondary gout).Urolithiasis develops half suffering from the disease for which the excretion of uric acid in urine is greater than 1 g per day.Massive deposition of uric acid in the renal tubule system as well as in the ureters may cause acute renal failure.Renal disease is the second in frequency after chronic gouty arthritis and prognostically is the most serious manifestation of gout.The appearance of protein in the urine is observed in 20-40% of patients, and often hypertension.
first type of renal damage in gout - urate nephropathy - emptive involvement in the inflammatory process of interstitial kidney tissue and renal tubules.This process is caused by deposition of uric acid crystals in the parenchyma.It is noted that, the more pronounced signs of joint damage, the less distinct manifestation of nephropathy, and vice versa, severe damage to the kidneys can be combined with minimal signs of arthritis.Interstitial nephritis may be complicated urinary tract infection.22-25% of patients with gout die from chronic renal failure.
second type of kidney damage and other parts of the urinary system - the formation of uric acid stones, often prior joint damage.80% stones consist of uric acid are often mixed composition, and in some persons with a combination of calcium oxalate or phosphate.Gout is urine acidity, which promotes the deposition of urate (uric acid).The probability of the formation of kidney stones is directly dependent on the concentration of uric acid in the blood.Nephrolithiasis occurs in 50% of patients in whom the level of urate in the blood plasma than 12 mg per 100 ml.
By the nature of the flow are acute and chronic gout.
1. Increased uric acid levels in the blood.
2. Hereditary predisposition.
Common symptoms - it's a pain in the big toe.However, there may be affected, and other joints.Gout most often occurs in men.It is not always the cause of this disease is the excessive consumption of food and alcoholic beverages.However, can not escape from the well-known fact that in many cases of gout attacks occur after the Christmas feast!The mite introduced and stress.
suddenly develops inflammation of the joint, most often affects the joints of the foot.Attack begins, usually at night.Sharp pain occurs, rapidly growing swelling, swelling and redness of the skin over the joint.It may also increase and body temperature.Typically, the disease takes a few days even in the absence of treatment.
In chronic course of the process form tophi - subcutaneous nodules, painless at a palpation.Localized they are usually in the subcutaneous fat area elbows, calcaneal tendon and the pinna.
If kidney damage observed urination disorders and crystals in the urine.
Diagnostics disease includes:
1. X-rays of the joints;
2. blood test: a sharp increase in the level of uric acid;
3. presence of tophi;
4. urinalysis: Detection of urate;
5. renal ultrasound.
Treatment of the disease in the first place should be started with the power change.In the acute phase should be excluded from their diet of meat, fish, poultry, alcohol, beans and coffee.After calming down aggravation of these products it is recommended to limit significantly.Drug treatment is carried out by special protivopodagricakih and anti-inflammatory agents.
forecast disease next.If adequate treatment is slowing the inevitable progression of the disease.When kidney disease serious prognosis.Specific
no prophylaxis.To prevent acute attacks must be followed doctor's advice and diet.