Multiple Sclerosis Symptoms
Multiple Sclerosis - a disease of the central nervous system that is characterized by multiple lesions, an autoimmune disease of unknown etiology characterized by lesions of the white matter of the brain and spinal cord (demyelination) with the direct involvement of activated T-lymphocytes and macrophages.Genetic factors play an important role in the development of multiple sclerosis.It is a disease characterized by the destruction of the myelin layer comprising an outer protective covering of nerves within the central nervous system (brain nerve, optic nerves and spinal nerves).Myelin layer is composed mainly of fats;fats are insulation for nerves and keep the speed of nerve impulses.In multiple sclerosis, the myelin layer inhomogeneous field are destroyed and replaced by scar tissue.This process is known as multiple sclerosis.How to cure this disease folk remedies.
destruction occurs in many areas of the central nervous system, which gave rise to the name of the disease - diffuse (or multiple) scler
Current concepts of the pathogenesis of multiple sclerosis based on multifactorial inheritance disease, implying the involvement of several genetic loci that predispose to the development of the disease, and external factors.The combination of these effects produces a pathological process - chronic inflammation, autoimmunity, and demyelination.
Multiple sclerosis is associated with certain alleles of genes of the variable chains of HLA molecules - DR and DQ, which are inherited clutch.This haplotype, designated by the International Nomenclature of both DRB1 * 1501, DQA1 * 0102-DQB1 * 0602 corresponds Dw2 haplotype in cell typing.These genes are located on chromosome 6 in multiple sclerosis patients reveal their 60%, compared to 20% in the general population.
there is evidence also that the genetic predisposition to MS may be linked to loci of genes Ar-recognizing T-cell receptor, tumor necrosis factor, variable regions of heavy chain Ig, as well as genes myelin proteins (myelin basic protein and myelin oligodendrotsitarnogo. glycoprotein) and other
The cause of the disease is unknown;However, modern research shows that multiple sclerosis is an autoimmune disease in which the immune system attacks some of its own cells, taking them as a foreign body.Multiple sclerosis is rare in children and people older than 60 years;the first attack of the disease usually occurs between 20 and 50 years.
Multiple sclerosis has two main forms.When recurrent form of the disease, which affects about 70 percent of patients, number of episodes are separated by periods of normal or near-normal state.Such periods of well-being can be short or last for months or years.In some cases, recovery occurs forever, but many patients gradually progressive neurological disorder.
Another type of multiple sclerosis, chronic progressive, gradually amplified without periods of improvement.Occasionally the disease development is so rapid and severe that the patient can survive only a few months or years.In women, the disease is more common than in men.The average life expectancy after diagnosis is 35 years, but the destruction of the myelin layer may eventually lead to a simultaneous damage to nerves, muscles and sometimes the brain.However, many people have the functions of these bodies are stored for many years, and they are able to lead a normal life using maintenance therapy.Treatment is aimed at reducing the frequency and severity of seizures, the weakening of neurological complications and providing psychological support.
prognosis for life is most often favorable.