The total number of T - lymphocytes (CD3) Blood

August 12, 2017 17:51 | Assays


relative the total number of T-lymphocytes in the blood of adults is 58-76%, the absolute amount - 1,1-1,7h109 / l.

Mature T cells responsible for the cellular immune response and perform immunological surveillance for antigenic homeostasis in the body.They are produced in the bone marrow and differentiate into vee-lochkovoy gland where divided into effector (T cells, killer cells, T-lymphocytes delayed type hypersensitivity) and regulators of cillator (T-lymphocyte helper cells, T lymphocytes, suppressor) cells.Accordingly, the T-lymphocytes in the body perform two important functions: regulatory and effector.

effector function of T lymphocytes - specific cytotoxicity against foreign cells.The regulatory function (the system of T-helper cells, T-suppressor) is to control the intensity of the development of a specific immune response to foreign Ag.The regulatory effect of T lymphocytes to the cells of the monocyte-macrophage series are varied.The ability of T lymphocytes to produce cytokines s

ynthesized and enable them to participate not only in the regulation of immune function, but many vital processes.The basis of many diseases is the pathology of T-lymphocytes, which in some cases is directly related to their defeat, and in others is mediated through immune regulation violation.Reducing the absolute number of T-lymphocytes in blood indicative of cellular immune deficiency, increasing - for immune hyperactivity and the presence of immunoproliferative diseases.

development of any inflammatory process on almost all its length is accompanied by a decrease in the content of T-lymphocytes.It occurs when inflammation of the most diverse etiology: various infections, nonspecific inflammation, destruction of damaged tissues and cells after surgery, injury, burns, heart attack, destruction of malignant tumor cells, etc.The degree of decrease in the number of T-lymphocytes in general, depends on the intensity of the inflammatory process, although this pattern is not always observed.Increasing the number of T-lymphocytes in the dynamics of the inflammatory process is considered a favorable sign, but high levels of T-lymphocytes in sharply marked clinical manifestations, on the other hand, an unfavorable sign, indicating a tendency to chronicity.Full completion of the inflammatory process is accompanied by a normalization of the number of T-lymphocytes.Increasing the relative amount of T-lymphocytes is not of great clinical value, but an increase in the absolute number of T-lymphocytes in the blood is very important for diagnosis of leukemia.