T -helper lymphocytes (CD4) in the blood

August 12, 2017 17:51 | Assays

Normally relative number of T-lymphocyte helper cells in the blood of adults is 36-55%, the absolute amount - 0,4-1,1h109 / l.

T-lymphocyte helper - inducer of the immune response, regulate the strength of the immune response to a foreign Ar and control the constancy of the internal environment (antigen homeostasis).The increase in the number of T-lymphocyte helper indicates hyperactivity of immunity, reduction - of immune deficiency.

primary importance in assessing the state of the immune system has a ratio of T-helper and T-suppressors in peripheral blood, as it affects the intensity of the immune response.In normal cells, and cytotoxic antibodies should be developed as much as they need to remove this or that Ar.Insufficient activity of T suppressor leads to the predominance of the effect of T-helper cells that contributes to a strong immune response (antibody production severe and / or prolonged activation of T effector).Excessive activity of T-suppressors, on the contrary, leads to rapid suppressi

on of abortive and downstream of the immune response, and even the phenomenon of immunological tolerance (immunologic response to Ag does not develop).With a strong immune response may develop allergic and autoimmune processes.High functional activity of T suppressor does not allow to develop an adequate immune response, in connection with which the clinical picture is dominated by the immunodeficiency-ing infection and susceptibility to malignant growth.The value of CD4 / CD8 1,5-2,5 index corresponds normergichesko th state;2,5 - hyperactivity;less than 1 - immunodeficiency.In severe inflammation within the ratio of CD4 / CD8 may be less than 1. The fundamental value of this ratio is in the evaluation of the immune system in patients with HIV infection.Selectively HIV attacks and destroys CD4-lymphocytes, resulting in the ratio of CD4 / CD8 decreases to values ​​much below 1.

Increased CD4 / CD8 ratio (3) are often noted in the acute phase of various inflammatory diseases, by increasing the number of Thelper cells and decrease T-suppressors.In the middle of an inflammatory disease of slow reduction of T-helper cells and increase of T-suppressors.When calming the inflammatory process, these indicators and their relations are normalized.Increased CD4 / CD8 ratio is typical for almost all autoimmune diseases: hemolytic anemia, immune thrombocytopenia, thyroiditis Hashi-moto, pernicious anemia, Goodpasture's syndrome, lupus, rheumatoid arthritis.Increased CD4 / CD8 ratio by reducing the number of CD8-lymphocytes in these diseases are usually detected at an aggravation and a high activity of the process.Reduced CD4 / CD8 ratio due to increasing amount of CD8-lymphocytes characteristic for a number of tumors, including Kaposi's sarcoma.Diseases and conditions that lead to a change in the number of CD4-lymphocytes in the blood, are presented in Table Table ..

Diseases and conditions that lead to a change in the number of CD4 blood

Table Diseases and conditions that lead to a change in the number of CD4 blood