Chronic glomerulonephritis

August 12, 2017 17:51 | Genetic Diseases

Chronic glomerulonephritis - a group of kidney diseases characterized by constant progressive inflammatory, sclerotic and destructive lesions of the kidney tissue with subsequent sclerosis and frequent development of chronic renal failure.

Chronic glomerulonephritis is usually a primary chronic disease, ie. F. Develops independently, without prior renal disease.The disease has a clear genetic predisposition.The factors triggering disease onset, may play a role: inappropriate drug therapy (long-term use of toxic for medications kidney), chronic foci of infection (carious teeth, chronic tonsillitis, adenoids), chronic viral infections (hepatitis B), excessive exercise alien to the bodysubstances (infection, repeated administration of antibodies, improper vaccination).

The basis of the disease is a violation on the part of the immune system.The normal kidney tissue separated from human blood and kidney proteins are "alien»

for the body.In case of violation of the integrity of the barrier which separates

the blood from the kidney tissue, the kidneys of these foreign proteins (antigens) into the bloodstream.Damage to the barrier may be influenced by various factors, for example under the influence of drugs, a variety of toxins and viruses.Also, the barrier may be broken in renal hypoplasia.The consequence of this is the development of antibodies to the body's own proteins (autoantibodies) that cause damage to the kidneys.In addition, chronic glomerulonephritis can develop as a result of disorders of the immune system function, in which the possible autoimmune process in kidney tissue intact.

manifestation of the disease is determined by the form of chronic glomerulonephritis.

When hematuric form of the disease onset is often difficult to establish (a small amount of blood in the urine is often detected by chance).Such people usually do not bother, blood pressure usually remains within the normal range (elevated only in 7-10% of cases), temporary swelling may occur;urinary disturbances and signs of intoxication are absent.Sometimes there is skin pallor, abdominal pain or back pain, fatigue, headache.The main feature of the disease - persistent presence of blood in the urine (hematuric syndrome) whose degree of severity can vary.Kidney function can be compromised.

edematous proteinuric forms of chronic glomerulonephritis usually has an acute onset.After undergoing a respiratory infection, sore throat, vaccine refrigeration, and sometimes seemingly without reason there are all signs of acute renal disease with a massive release of protein in the urine.The main manifestations of the disease are: a massive release of protein in the urine (proteinuria), swelling of varying severity, decreased protein content in the blood serum (hypoproteinemia), increased lipid content in the blood (hyperlipidemia).Perhaps the increase in blood pressure and the appearance in the blood of nitrogenous wastes that disappear relatively quickly with treatment.

disease occurs long, wavy.For a long time the excretion of metabolism (nitrogen compounds) by the kidneys is not broken products, but eventually develop chronic kidney failure.

mixed form of chronic glomerulonephritis usually begins with acute nephritis, but difficult to treat.For this type is characterized by abdominal pain or lower back pain, urinary disorders, the appearance of pronounced edema, increased blood pressure, headache, dizziness, irritability or drowsiness, blurred vision, and sometimes paralysis of the facial nerve, vomiting, decreased reflexes, incoordination, convulsions.Blood pressure is much higher than the age regulations.Fundus examination reveals signs of injury as a result of high blood pressure.In a laboratory study to detect changes in the urine (blood, a large amount of protein), reduced protein content in the blood and increase the lipid content.In this form of the disease, chronic renal failure develops within 1-2 years of the disease.Treatment

chronic glomerulonephritis administered individually, depending on the shape and course of the disease, the presence and stage of renal failure, and complications associated diseases.Basic therapy includes diet, regime compliance, herbal medicine and treatment of chronic infection foci (carious teeth, tonsillitis, adenoids).

diet depends on renal function.During an exacerbation in children with chronic glomerulonephritis option hematuric diet build the image appointed in acute glomerulonephritis: limit the amount of fluid expelled from table salt diet, limit the amount of protein.At an exacerbation in children with hematuric and mixed forms of current recommended salt-free low-protein diet (daily amount of protein of about 1 g / kg).Expansion of the diet and increase the amount of protein is carried out slowly to prevent exacerbations of the disease.

Bed rest is prescribed only in acute diseases.

Herbal medicine can be conducted for a long time (months or years), and may include a separate infusions of herbs and various fees.The composition of the collection should include the following components: lavender Kolosov, black currant, a piece of white birch, fruits Juniperus, the cones of hop ordinary, petals Crimean rose, leaf bearberry, cowberry leaves, leaf plantain, nettle, fruit cinnamon wild rose, wild strawberry berries, horsetail shoots field.

drug therapy appoint a physician taking into account the type of glomerulonephritis, which is also determined by a doctor.

Prevention of chronic glomerulonephritis involves timely detection and treatment of chronic foci of infection (carious teeth, adenoids, chronic tonsillitis), adequate and timely treatment of acute glomerulonephritis, the rational use of drugs that have toxic effects on the kidneys.

prognosis of chronic glomerulonephritis depends on the form of the disease.But in most cases of chronic glomerulonephritis - a disease with a steady progression, gradually leads to sclerosis of renal tissue and the development of chronic renal failure.

Clinical supervision in chronic glomerulonephritis is performed prior to the transfer of the child under the supervision of an adult clinic.Visit a doctor with blood pressure measurement and urine tests performed in the first 12 months after the exacerbation of 1 time per month in the future in the absence of exacerbations - 1 time per quarter.Visit the dentist, otolaryngologist, an ECG is performed 1 time in half a year.

Drug therapy is prescribed depending on the shape and characteristics of the disease.