Urine acid diathesis

August 12, 2017 17:51 | Genetic Diseases

Uric acid is the final product of one of the types of metabolism.Risk of crystallization occurs when the concentration of uric acid in excess of a certain threshold.

term « urate diathesis » inducted NF Filatov in 1902. In 1985 it was carried out the mass examination of children on hyperuricemia (elevated levels of uric acid in the urine), which was detected in 16% of children surveyed.However, most of them it was symptomatic transient and has been associated with kidney disease, cardiovascular system, blood, as well as power character.Children with excess uric acid levels in the blood have a high incidence of nervous and mental disorders (neurotic reactions, systemic and multiple neurosis, pathological characterological reactions).With hyperuricemia associated the following symptoms: a high level of intellectual development, obesity, hypertension and cardiovascular disease.The causal relationship between hyperuricemia and disorders of the central nervous system, as well as the defeat of the cardiovascu

lar system are unclear, but there is an opinion about such a connection with kidney disorders.

Boys with hyperuricemia more often than girls, there are hyperkinetic syndrome (hyperexcitability syndrome), bedwetting (enuresis), anorexia (loss of appetite, until the complete lack of it), in girls - obesity, urinary and gastrointestinal syndrome.Children under three years are more likely than in other periods, marked regurgitation, vomiting, sleep disturbances, appetite, stool frequency (dyspeptic syndrome).In the age group 4-7 years to the fore hyperkinetic syndrome, motor disinhibition, logoneurosis (speech impairment), behavioral responses (negativity), urinary syndrome, abdominal pain.In children 8-10 years marked tendency to increase further symptoms of the urinary system, arthralgia (joint pain).In 11 - 14 years increased the frequency of dystonia syndrome affective excitability, negative behavioral reactions.

In the first days after birth, levels of uric acid in blood plasma is usually elevated, but the 5th day of life, he is reduced.Excessive excretion of uric acid by the kidneys is the cause urate infarction in the newborn.

During growth vary the ratio of uric acid and urea, which are excreted by the kidneys.Superfine (in relative terms) the excretion of uric acid occurs within the first 3 months of life.During the first two years of the excretion of uric acid is higher than in the adult, per 1 kg of body weight.It binds to specific features of metabolism in the body of the child.

Possible causes hyperuricemia:

1) increased purine intake from food (meat);

2) increased production of uric acid in result of numerous diseases;

3) violation of excretion of uric acid by the kidneys: chronic renal failure, starvation, lead poisoning, the effect of diuretics (diuretics), Down syndrome, hypothyroidism;

4) insufficient excretion of uric acid from the body through the intestines.