hypergonadotrophic amenorrhea

August 12, 2017 17:51 | Genetic Diseases

The disease is cessation of menses due to excessive formation in a woman's pituitary hormones (brain iron) that stimulate ovarian function.The normal ovarian (ovarian) deficiency occurs in all women at menopause, when there is a physiological ovarian exhaustion. hypergonadotrophic amenorrhea may be caused by a variety of genetic disorders.Congenital anomalies of sexual development is usually accompanied by high levels of gonadotropins (pituitary hormones that affect the sexual glands of women) and the absence of menstruation (amenorrhea).

depleted ovarian syndrome - the onset of irreversible amenorrhea in women younger than 37-38 years, who had last normal menstrual and reproductive function, as a result of genetically determined disease of the ovaries.

In the development of this disease is considered to be a leading factor in the presence of chromosomal abnormalities that lead to the formation of small ovarian follicular apparatus with a deficit.In 46% of cases the first and second relative (mother a

nd daughter, or sister) have kinship degrees of menstrual dysfunction and early development of menopause.Probably on the background of genetic predisposition of any external influences (stress, infections, intoxication, irradiation, starvation) can lead to dysfunction of the follicular apparatus of the ovaries.Various adverse factors affecting the female body, contribute to the period before and after puberty destroy germ cells, damage to the reproductive glands and their replacement by connective tissue.

The disease begins with the fact that menstruation becomes, in comparison with conventional, leaner and less prolonged.Such changes usually last from six months to three years.Another onset may appear abrupt cessation of menstruation at all.Against the backdrop of the emerging shortage of female ovarian hormones (ovarian gipoestrogeniya) after the cessation of menstruation in women develop a set of symptoms typical of menopause syndrome.At the same time there are the following symptoms: headaches, depression, "tides", impaired concentration, anxiety, decreased libido and ability to work, dry vagina, vagina inflammation, urogenital disorders, various metabolic disorders, increased incidence of cardiovascular diseases and disorders,often develop osteoporosis.

gynecological examination reveals a decrease in size of the uterus and ovaries.Rectal temperature (rectal temperature) at any measuring time remains unchanged.The changes observed in the US, are identical to the changes arising after menopause.At the same time there is a progressive reduction in size of the uterus and ovaries.The follicles of the ovaries are not detected.When hormonal research note dramatic changes in hormonal levels.

For detection of the disease is carried out histological examination of ovarian tissue, in which the characteristic changes detected.In addition, necessary is to carry out tests with hormones.This cyclical administration of female sex hormones leads to improved well-being of women and the appearance of the body's reaction identical to the onset of menstruation.

criteria for the diagnosis of depleted ovary syndrome are the following features: permanent cessation of menstruation and infertility at the age of 37 years;normal menstrual function in the past;typical climacteric syndrome;typical hormonal changes in laboratory blood analysis;the absence of ovarian follicles and atrophy, determined by histological study of body tissue.

depleted ovary syndrome should be distinguished from sindromarezistentnyh (resistant) ovarian.resistant ovary syndrome is characterized by the cessation of menstruation, infertility, normal development of secondary sexual characteristics, a set of female sex chromosomes (46, the XX-th), a moderate increase in the level of the pituitary gonadotropin-releasing hormone, a moderate decrease in female sex hormones (estrogen).In this syndrome are identified properly formed, a few immature ovaries with ample follicles.It is believed that the disease is transmitted inheritance of autoimmune type, in which the formation of antibodies in women receptors for affecting the ovaries pituitary hormones.It is believed that prolonged administration of high doses of gonadotropins may be activation of ovarian function up to complete its recovery.

criterion setting syndrome diagnosis of drug-resistant ovarian is the presence of a woman following features: reversible (in contrast to the above diseases) cessation of menstruation and infertility at the age of 37 years;normal menstrual function in the past;you have all the signs of the climacteric syndrome;characteristic changes in hormonal levels in the study of blood serum;a sufficient number of follicles, determined by histological study of body tissue.The decrease

ovarian functional activity might also be of different organ lesions involving exposure to radiation or chemotherapeutic agents (especially useful in the treatment of various cancers).The menstrual cycle and ovulation in some women may be able to recover even after a long period of existence of the disease and pronounced reduction of female hormones (estrogen).

The literature describes cases of ovarian failure in women who have had mumps infection, as well as after severe inflammatory processes in the pelvic area.Surgical castration also leads to the development hypergonadotrophic amenorrhea.

treatment. All women with amenorrhea hypergonadotrophic, regardless of the presence or absence of these manifestations of reducing the formation of estrogen replacement therapy is prescribed sex hormones, which takes place before the age of natural menopause and beyond.In the absence of contraindications pregnancy in women with this disease is possible with artificial fertilization sperm donor eggs husband in a test tube, followed by transferring the resulting embryo into the prepared uterus.Such methods have been made possible by the development of in vitro fertilization programs.