plasma lipidoses

August 12, 2017 17:52 | Genetic Diseases

Plasma lipoidozy - hereditary diseases, common feature of which is the high level of fats (lipids) in the blood plasma.Another name for this disease - familial hyperlipidemia.Plasma lipoidozy divided into 5 types.

Hyperlipidemia type I is characterized by a significant and persistent increase in the lipid content in the blood plasma.The amount of lipids in the blood is reduced if a person observes a diet containing no fat.The main signs of illness are attacks of abdominal pain, which may be accompanied by fever, and the blood may increase the number of leukocytes (white blood cells).A characteristic feature also serves as an enlarged liver and spleen.Excessive increase in total lipid content in the blood to the extremities skin, back and buttocks appear xanthomas, which are often surrounded by redness area.If blood levels of total lipids decreases, xanthoma disappear leaving stain darker color compared to the rest of the skin.lipid deposition in the passage of the optic nerves can be a cause of blindnes

s for a given disease.

Hyperlipidemia type II is very similar to type I.The difference is that in this type of disease observed delay of mental development of the child, the appearance of xanthomas is not typical.

Hyperlipidemia type III appears xanthomatosis and early development of atherosclerosis (deposition of fatty plaques on the inner surface of blood vessels).On tulovisha skin, face, extremities may show xanthomas, which are located in the area of ​​the tendon location.lipid deposits - xanthelasma - found on the eyelids and the cornea of ​​the eye.The appearance of the lipid formation in the blood vessels can lead to the early emergence of symptoms of angina and even heart attack.The appearance of fatty plaques in the heart valves leading to the development of chronic circulatory failure.In this disease, the formation rate of fatty plaques in blood vessel walls is independent of the amount of lipids in the blood.The disease is combined with the hidden or easily flowing diabetes, which is revealed only during the stress tests.

Hyperlipidemia type IV is very similar to type III.To distinguish these two types of the disease is possible only after the biochemical analysis of blood.

Hyperlipidemia type V is also compatible with latent or easily flowing diabetes.Manifestations of the disease combines the features of types I and III hyperlipidemia.These manifestations are abdominal pain, xanthomatosis, enlarged liver and spleen, the tendency to early development of atherosclerosis and myocardial infarction.

All types considered violations of lipid metabolism transmitted in an autosomal recessive inheritance type.hyperlipidemia treatment mainly consists in a diet with restriction of products containing animal fats.These fats are replaced by vegetable oils.Reduction in blood lipid content occurs during treatment with large doses of nicotinic acid.When III, IV and V types lipoidozov plasma may be necessary to limit carbohydrates in food, in cases of overt diabetes insulin applied.Some positive effect on types I and V lipoidozov achieved by use of heparin or analogues thereof.The manifestations of angina require appropriate treatment: no-spa, nitroglycerin and other drugs used to treat this disease.

forecast largely determined by the degree and pace of development of atherosclerotic changes in vessels of the heart and brain.The faster is the formation of fatty plaques on the inner vessel surface, the worse the prognosis, and vice versa.