Symptoms of Psoriasis - Causes, Symptoms and Treatment .MF .
Psoriasis (psoriasis) - one of the most common diseases of the skin, refers to chronic diseases, which takes place over the years, accompanied by alternating exacerbations and external health.According to statistical data presented by different authors, the disease affects about 2% of the population.
main symptoms of psoriasis
Psoriasis is characterized by monomorphic rash in the form of nodules (papules) with a diameter of 1-3 mm to 2-3 cm or more, pink-red, covered loosely seated silvery-white scales.When poskablivanii papules exhibit characteristic symptoms of psoriasis, "stearin spot", "terminal film", "blood dew".
developing the disease in different patients in different ways.The most common early in the disease rash is not a lot, they can be stored for a long time in the same places, especially on the scalp and in the large joints, gradually increasing in size, usually under the influence of kakih-libo provoking factors (trauma, violation of the diet,pregnancy or childbirth, and others.).After
Psoriasis on the elbow
In the development of the disease, increasing the number of elements and their peripheral growth papules coalesce to form plaques of different sizes and shapes.
characteristic of psoriasis is the Koebner phenomenon (isomorphic reaction symptom), when the site of injury or scratches appear characteristic for the disease psoriatic papules.
Psoriasis most often localized on the extensor surfaces, especially in the elbow and knee joints.Rashes can affect the skin of the body.Often the affected scalp.
In psoriasis distinguish progressive, stationary and retrogressive step.For advanced stage characterized by the appearance of new areas of the skin of a large number of small, the size of a pinhead, nodular lesions, there is a tendency to peripheral growth elements and the development of psoriatic plaques.
In stationary stage new items do not appear.Available papules on the skin longer increasing.
psoriasis flow regress stage is characterized by a flattening of psoriatic plaques, decrease resorption and peeling elements, which often begins with the central part.At the site of lesions regressed, as a rule, are depigmented spots.
psoriasis symptoms, depending on the classification
Distinguish following clinical variants of psoriasis: general, exudative, Arthropathic, erythrodermic psoriasis and pustular psoriasis.
Exudative psoriasis different from the usual symptoms of psoriasis significant exudation (weeping), as a result of which on the surface are formed papules plate scaly yellowish crusts.When removing from the surface of these papules crusts exposed weeping and bleeding surface.
pustular psoriasis can manifest as generalized or palmar-plantar form.Generalized pustular psoriasis runs hard, with fever, malaise, leukocytosis, elevated erythrocyte sedimentation rate.Paroxysmal against a bright erythema superficial pustules appear small, soreness and burning sensation accompanied located in plaque area and on the skin has not previously modified.Pustular psoriasis of the palms and soles is more common than generalized form.The rash is usually symmetrical and there are intraepidermal pustules on a background of a sharp hyperemia, infiltration, and lichenification.
Arthropathic psoriasis is characterized by a typical skin rash, accompanied by joint disease, mostly small (hands and feet), rarely larger.The range of symptoms can vary from minor arthralgia, especially in the beginning to the disabling condition.Most often affects the distal joints.At the beginning of the disease are observed mono- or oligoarthritis, usually asymmetric, with the progressive course may develop generalized joint disease.There have been swelling, pain, limited mobility of the joints as a result of infiltration and seal para-articular tissues.In the further course of the process can form dislocations, subluxations, ankylosis, leading to deformation of joints, and often occurs patient disability.
Psoriatic erythroderma - sharply growing, generalized process characterized at its peak the following symptoms: sudden hyperemia (redness), swelling, infiltration and lichenification, with a large number of scales on the surface.The patient has a fever, there are pains in the joints, worsening overall health.Erythroderma may develop due to the gradual progression of psoriatic process, the merger of plaques, as well as under the influence of provoking factors, among which the most unfavorable excessive sun exposure, an overdose of ultraviolet rays or the use of them (as well as irritating external agents) in an advanced stage.
In psoriasis can occur defeat nail manifested point depressions on the surface of the nail plate (a symptom of "thimble"), or clouding of the appearance of longitudinal and transverse grooves.Sometimes a thickened nail plate, deformed, their surface is uneven.In other cases, the nails crumbling, broken and rejected.
pathognomonic signs of psoriasis is a significant presence of acanthosis with elongated epidermal outgrowths several thickened in their lower part.
over the tops of dermal papilla sometimes thinned epidermis, characterized by parakeratosis, and in old foci - hyperkeratosis.Granular layer pronounced uneven sections under parakeratosis - absent.At an advanced stage in the thorny layer is marked inter- and intracellular edema, exocytosis with the formation of focal accumulations of neutrophilic granulocytes, which are migrating into the stratum corneum, or parakeratoticheskie areas form microabscesses Munro.The basal and lower ranks of the thorny layer often exhibit mitosis.Accordingly, elongation of epidermal outgrowths dermal papillae elongated and enlarged, sometimes kolboobrazno, swollen, blood vessels in them meandering, full of blood.In papillar layer marked perivascular infiltrate of lymphocytes and neutrophils.
symptoms depending on the cause
Psoriasis - multifactorial disease.There are two types of psoriasis.Psoriasis is associated with type I HLA antigen system (HLA Cw6, HLA B13, HLA B 17).This type of psoriasis suffers 65% of patients, the disease accounts for debut at a young age (18-25 years).Psoriasis type II is not associated with HLA antigen system and occurs at an older age.
Undoubtedly, a major role in the pathogenesis of psoriasis play changes in the immune system caused by either genetic or acquired under the influence of external and internal factors.Provoking moments may be the injury of the skin, stress, use of certain medications, alcohol abuse, infectious diseases (particularly those caused by streptococcus, viral diseases) and OE
Disorders of the immune system identifies both the cellular and humoral level and are to change the basic content of the immunoglobulinclasses of circulating immune complexes in a pool of lymphocytes of peripheral blood B- and T-lymphocyte populations and subpopulations, killer cells, phagocytic activity of leukocytes segmented.
believed that primary changes in psoriasis occur both at the level of cells of the dermal layer and the epidermis.Dysregulation of dermis cells cause excessive proliferation of normal epidermis mainly.
hyperproliferation of keratinocytes leads to the secretion of cytokines and eicosanoids, which exacerbate skin inflammation.The lesions epidermal cells presenting antigen, produce interleukin-1.Probably, interleukin-1 factor is identical to T-cell activation epidermis (ETAF), which is produced by keratinocytes and activated lymphocytes of the thymus.Interleukin-1 causes chemotaxis of T lymphocytes, and by promoting their migration into the epidermis may be responsible for the infiltration of these cells of the epidermis.
interleukins and interferons, produced by T lymphocytes can themselves be mediators in the processes of hyperproliferation of keratinocytes, as well as mediators of inflammation and thus contribute to the maintenance of the vicious circle,which defines chronic psoriasis.
Just these factors and determine the development of complications of the disease and the patient's tendency to diseases of other organs and systems.
psoriatic arthritis as a complication of psoriasis
By kaomu doctor ask for suspected psoriasis
the disease has been dermatologist.