Gigantism - Causes, Symptoms and Treatment .MF .

August 12, 2017 17:52 | Endocrine Diseases

Gigantism - a disease in which there is increased production of growth hormone (HGH), which in turn leads to excessive proportional increase in the limbs and trunk.

Understanding gigantism Gigantism

- a disease in which there is increased production of growth hormone (HGH), which in turn leads to excessive proportional increase in the limbs and trunk.In men with the disease growth exceeds 200 cm and women -. 190 cm more often seen in men aged 7-13 years (puberty) or at puberty and continues throughout the physiological growth period.Indicators of child growth and the growth rate higher than the norms of the age and sex.

Gigantism is not to be confused with high growth.Parents of persons suffering from the disease mostly normal growth.

symptoms of gigantism

patients have typical complaints: high growth and significant of his pace, ALS Bost, fatigue, decreased performance and school performance, headaches, dizziness, pain in the extremities, sometimes - blurred vision.Muscle strength can be inc

reased first, but further considerably reduced.

An objective examination, that is, during the inspection revealed: high growth, proportional body, the normal sexual development, but often celebrated for its support.Possible violations of the thyroid and pancreas.Pronounced changes in the other endocrine glands and internal organs were observed.

reasons gigantism

disease is based on increased production of growth hormone, which can develop under the following lesions:

  • tumor adenohypophysis;
  • neuroinfections (an infectious (bacterial or viral) disease of the central nervous system, such as meningitis, encephalitis, meningoencephalitis);
  • intoxication (poisoning toxins);
  • traumatic brain injuries.

also cause gigantism may be a reduction of the sensitivity of the receptors of the epiphyseal cartilage (part of the bone in which there is its growth in length) to sex hormones, resulting in a zone of growth of bones for a long time remain open (ie, retain the ability to further growth) and after the completion of puberty (7-13 years).


Complications The main complication is acromegaly.

Diagnostics gigantism

Laboratory studies with gigantism without significant changes, however, the content of growth hormone in the blood increased.

as instrumental studies using radiography, computed tomography of the brain.Abnormalities detected in tumors of the pituitary gland.If you have a growing adenoma (benign tumor) of the pituitary occurs withdrawn chenie sella size (of the skull where the pituitary gland is located).The X-ray bones of the hand is determined by the backlog of bone age of the passport.When growing adenoma marked limitation of field of vision (blurred vision).

With the continuing development of active growth hormone after skeletal maturation is formed acromegaly.

When gigantism examination is the same as in acromegaly.

Treatment gigantism

Modern treatments include a combination of hormones and radiation therapy, are showing positive results in many cases.When the pituitary tumor lesion shown surgical intervention.Treatment is basically the same as in acromegaly.