Complete blood count , erythrocyte sedimentation rate - Causes, Symptoms and Treatment .MF .
Complete blood count prescribe virtually all diseases, pregnancy, and as a preventive measure for the detection of diseases.Total blood taken from the finger.
General blood test involves determining the concentration of hemoglobin, red blood cell count, white blood cells and platelets, hematocrit values and erythrocyte indices (MCV, MCH, MCHC).
Indications for general analysis of blood and ESR
General blood test, together with leukocyte formula is widely used as one of the most important methods of inspection in most diseases.Changes in the peripheral blood, non-specific, but at the same time reflect a change in the whole organism.
study leukocyte is of great importance in the diagnosis of hematologic, infectious, inflammatory diseases, as well as assessing the severity of the condition and effectiveness of the therapy.At the same time, changes in leukocyte counts are not specific - they can be similar in nature with various diseases or, alternatively, changes can occur unlike in the same dis
erythrocyte sedimentation rate (ESR):
screening tests during routine inspections.
measurement of erythrocyte sedimentation rate should be regarded as a screening test, which is not specific to some particular disease.ESR is normally used in general blood test complex.
Preparation of general analysis of blood and ESR
General blood test is carried out on an empty stomach. between the last meal and blood donation in the overall analysis must be at least 8 hours.It is advisable for 1-2 days before the examination to exclude from the diet of fatty, fried foods and alcohol.One hour prior to blood sampling is necessary to refrain from smoking.
necessary to exclude the factors affecting the results of research: physical exertion (jogging, climbing stairs), emotional excitement.Before the procedure need to rest for 10-15 minutes, to calm down.
About medication be sure to tell your doctor.
Blood should not donate after radiography, rectal examination or physiotherapy.
different research methods and measurement units can be used in different laboratories.To estimate the results were correct, we are sure to place the study in the same laboratory at the same time.Comparison of these results will be more comparable.
Deciphering blood count
Modern hematology analyzers provides accurate and highly informative characteristics of blood cells.
Any change in the general analysis of blood and abnormalities treated as pathological and require careful examination of the patient .Changes in the hemogram in many diseases can be nonspecific.In this case, they are used for dynamic monitoring of patients in terms of prognosis estimation.
In diseases of the hematopoietic system study blood count is of paramount diagnostic importance.It determines the future strategy of the patient survey, followed by selection of treatment regimens and it is necessary to monitor the therapy.
In hematology analyzers of various companies producing normal blood values can vary significantly depending on the rules used in a particular country.Below normal peripheral blood counts in adults according to the order of the Russian Federation MZSR.
blood parameters Standards
|Indicator blood||Normal values |
| Hemoglobin, g / l |
| Red blood cells (RBC), * 1012 / l |
| hematocrit,% |
|Average hemoglobin content in an erythrocyte (MCH), pg||27,0-31,0|
|mean corpuscular volume (MCV), fl, mkm3||80,0-100,0|
|average concentration of hemoglobin in the red blood cell (MCHC), g / dL||30,0-38,0|
|erythrocyte distribution width by volume (RDW-CV),%|| 11,5-14,5 |
|Reticulocytes, ‰ (or%)||2,0-12,0 (0,2-1,2)|
|leukocytes * 109 / l||4,0-90|
| Neutrophils% (109 / l) |
|Platelets * 109 / l||180,0-320,0|
|mean platelet volume (MPV), fl||7,4-10,4|
|platelet distribution width by volume, (PDW),%||10-20|
|ESR, mm / h||2,0-20,0|
erythrocyte parameters (parameters) of blood
- mean corpuscular volume
- Average hemoglobin content in an erythrocyte
- average concentration of hemoglobin in the red blood cell
- index anisocytosis (heterogeneity) of red blood cells (RDW - red cell distribution width)
- morphology of red blood cells
- erythrocyte sedimentation rate (ESR level)
platelet blood parameters
- platelets (PLT - platelet)
- mean platelet volume (MPV - mean platelet volume)
- platelet distribution widthby volume (PDW - platelet distribution width)
- Thrombocrit (PCT - platelet crit)
leukocyte blood parameters
- number of leukocytes
- Plasma cells
- Atypical mononuclear
leukocyte formula - is the percentage of different types of white blood cells (neutrophils, lymphocytes, eosinophils, monocytes, basophils).Wbc includes determining (in%) of neutrophils, lymphocytes, eosinophils, basophils, monocytes.
erythrocyte sedimentation rate (ESR)
erythrocyte sedimentation rate (ESR) - a nonspecific indicator of inflammation.
sedimentation rate - an indicator of the separation of blood velocity in the test tube with the added anticoagulant into 2 layers: the top (transparent plasma) and lower (settled erythrocytes).Erythrocyte sedimentation rate is measured at the height of the resulting plasma layer (in mm) for 1 hour.The specific gravity of red blood cells is higher than the specific weight of the plasma, so in vitro in the presence of anticoagulant (sodium citrate) under the action of gravity RBCs settle to the bottom.
process of settling (sedimentation) of erythrocytes can be divided into 3 phases, which take place at different speeds.First, the red blood cells slowly accumulate individual cells.Then they form aggregates - "coin columns", and settling is faster.In the third phase formed by a lot of units of red blood cells, their first subsidence slows down and gradually stops.ESR
display varies depending on a variety of physiological and pathological factors.ESR values in women is slightly higher than that of men.protein composition of the blood changes during pregnancy lead to increased erythrocyte sedimentation rate in this period.
Reduction of red cells (anemia) in the blood leads to acceleration of erythrocyte sedimentation rate and, conversely, increased blood erythrocyte sedimentation rate slows.During the day, maybe the oscillation values, the highest level observed in the daytime.The main factor influencing the formation of "rouleaux" in the erythrocyte sedimentation rate is the protein composition of blood plasma.Acute phase proteins adsorbed on the surface of red blood cells, reducing their charge and the repulsion of each other, contribute to the formation of "rouleaux" and accelerated erythrocyte sedimentation.Increasing
acute phase proteins, such as C-reactive protein, haptoglobin, alpha-1-antitrypsin, acute inflammation increases the ESR.In acute inflammatory and infectious processes of change in the erythrocyte sedimentation rate observed 24 hours after the rise in temperature and an increase in the number of leukocytes.In chronic inflammation increased erythrocyte sedimentation rate due to increased concentrations of fibrinogen and immunoglobulins.
Westergren method differs from the common method of determining the erythrocyte sedimentation rate in device Panchenkova characteristics of tubes used and the results of the scale calibrated in accordance with the Westergren method.The results obtained by these two methods are identical in the normal range, both methods have the same reference ranges.Westergren method is more sensitive to an increase in erythrocyte sedimentation rate, and results in the area of high values obtained by Westergren above results obtained by Panchenkova.
Definition ESR dynamics, in combination with other tests are used to monitor the effectiveness of treatment of inflammatory and infectious diseases.