Determine the level of dehydroepiandrosterone - Causes, Symptoms and Treatment .MF .

August 12, 2017 17:52 | In Gynecology

Dehydroepiandrosterone (DHEA) - is an androgen, which refers to the 17-keto steroids;It is secreted by the adrenal cortex netted area.It has a short half-life and the maximum concentration in the blood in the morning.DHEA into androstenediol catabolized, Tc and 5.alpha.-dihydro-Tc.

DHEA is a very sensitive indicator of the activity of androgen synthesis in the adrenal glands.It is indispensable for the differential diagnosis of the origin and definition of the syndrome virilnogo hyperandrogenaemia source: adrenal or ovarian disease.Moreover, this indicator is required when assessing the function of puberty in children, as the increase in the level of DHEA in the blood correlates well with the development of secondary sexual characteristics.

When determining the interpretation of the results of the blood levels of DHEA expressed need to consider the variability of the rhythm of its secretion.Therefore, a more informative to determine the level of DHEA-sulfate, absolute blood which is 300 times higher t

han that of DHEA.The long half-life, the lack of circadian rhythm of secretion and binding to blood transport proteins determine its stability and reliability for a specific interpretation of laboratory results as a specific marker of adrenal androgen secretion.

testimony to the determination of DHEA-sulfate content:

• differential diagnosis of ovarian diseases, if there is an increased level of T, then by defining the DHEA-sulfate, can determine whether this is due to adrenal disease (androgeniziruyuschie tumor, hyperplasia, Cushing's syndrome, deficit21-hydroxylase or 11-.beta.-hydroxylase);

• adrenal tumors;

• osteoporosis;

• delayed puberty;

• early puberty.

Normal blood amounts (mg / 100 ml):

§ men (19-59 years) - from 35 to 441;

§ women (19-48 years) - from 10 to 333;

§ women (over 50 years) - from 32 to 204;

§ children (up to 1 month) - from 8.8 to 338;

§ children (1-11 years) from 0 to 90;

§ children (11-15 years old) from 20 to 263;

§ children (15-17 years old) from 30 to 238.

number of serum or plasma (EDTA, heparin) necessary for analysis - 0.1 ml, the analysis time of 3-4 hours.