Determine the level of testosterone - Causes, Symptoms and Treatment .MF .
Testosterone (T) - a steroid hormone with a molecular weight of 288.4.Produced by the adrenal cortex and ovaries in a ratio of 1: 1 in an amount of about 1 mg / day.Approximately 97-99% of the hormone circulates in the blood associated with beta-globulin and testosterone-binding globulin svyazshayuschim form.In the liver, occurs inactivation of T and turning it into a 17-KS.
androgens in the female body are the substrate for the formation of estrogen, as well as stimulate the pre-ovulatory LH surge.
Along with Tc ovaries form Δ4-androstenedione (Δ 4-SDA) -androgen, which refers to the 17-COP and is formed as the adrenal cortex.It is characterized by circadian rhythm of secretion with a maximum in the morning hours.In the menstrual cycle, the dynamics of the maximum level recorded in the ovulatory period.In peripheral tissues hormone converted to androgens (T and 5α-dihydro-Tc).Δ4-Level ASD increased in virility syndrome, hypercorticoidism, ovarian syndrome sclerocystic.
At low concentrations in blood
To evaluate peripheral effects of androgens indispensable is to determine the blood levels of 5.alpha.-digidrotestostsrona (5α-dihydro-Tc).This is formed in the peripheral androgen target tissues of Tc under the influence of 5.alpha.-reductase and stimulates the formation of hair in women.Its definition is indispensable for the diagnosis of congenital 5α-reductase deficiency.
previously widely used biochemical analysis of blood levels and excretion of total androgen - 17-keto steroids (17-KS).With the introduction into clinical practice methods of RIA and EIA, as well as, given the high cost and complexity of the biochemical method, the latter becomes superfluous.
testimony to the determination of the content of androgens in the blood:
· detection of disorders of the gonads and adrenal glands;
· diagnosis of hirsutism and virilism;
· Klinefelter syndrome and other chromosomal disease;
· androgensinteziruyuschie tumors of the ovaries, kidneys and adrenal glands;
· a violation of the male-type sexual orientation during puberty;
· sexual disorders in men and women.
Normal blood women Tc ranges from 0.2 to 1.0 ng / ml (0,3-5,4 nmol / l).
Number of serum required for analysis - 0.3 ml, the analysis time of 3-4 hours.