Testing for rheumatoid factor - Causes, Symptoms and Treatment .MF .

August 12, 2017 17:52 | In Immunology

Rheumatoid factor (RF, Rheumatoid factor, RF) - a test often has a key role in the diagnosis of rheumatoid arthritis and other rheumatic diseases.

Rheumatoid factor is an antibody reactive with their own antibodies.Rheumatoid factor is usually determined in the blood.In the most high-titer rheumatoid factor detected in rheumatoid arthritis, Sjögren's syndrome.It can also occur with other autoimmune diseases (scleroderma, dermatomyositis, lupus), certain blood diseases (Waldenstrom's macroglobulinemia), infectious diseases (syphilis, tuberculosis, subacute bacterial endocarditis, viral hepatitis, malaria, infectious mononucleosis), sarcoidosis.Thus the amount (titre) is usually less than in rheumatoid arthritis.

Note that rheumatoid factor can be detected at very many diseases.Its identification is not always indicative of the presence of rheumatoid arthritis and rheumatic disease even.Moreover, the detection of rheumatoid factor by itself does not indicates the presence of disease (especially in a sma

ll amount and / or the elderly).When interpreting the results it is necessary to take into account the clinical picture and other examination.

What is rheumatoid factor (RF, Rheumatoid factor, RF)?

These are special proteins autoantibodies to immunoglobulin G (IgG).In rheumatoid arthritis and certain other autoimmune diseases, there is a condition in which the immune system takes its own structure as a foreign body and starts producing autoantibodies, designed to eliminate the body's own tissues as foreign education.In rheumatoid arthritis, such autoantibody rheumatoid factor becomes, attacking the body's own for the G class immunoglobulins, change state under the influence of viruses or other negative impacts.Low values ​​of the Russian Federation has little diagnostic value.In children with juvenile rheumatoid arthritis RF often negative.Elderly patients elevated levels of rheumatoid factor can be determined without clinical manifestations of rheumatoid arthritis.Therefore, the increased value of rheumatoid factor must be confirmed by other laboratory and clinical data.

Indications for analysis to rheumatoid factor:

  • rheumatoid arthritis (definition of process activity, prognosis and monitoring of the treatment of the disease);
  • other autoimmune diseases;
  • chronic inflammatory diseases.

Preparing to study: blood samples is carried out on an empty stomach;exclude smoking.
Deadline: 1 working day.

When values ​​increased?

  • Rheumatoid Arthritis.
  • Sjogren's syndrome.
  • Scleroderma.
  • Dermatomyositis.
  • Waldenstrom's disease (macroglobulinemia).
  • Sarcoidosis.
  • Systemic lupus erythematosus.
  • Chronic inflammatory diseases: syphilis, tuberculosis, subacute bacterial endocarditis, chronic active hepatitis, malaria, infectious mononucleosis (usually titer of rheumatoid factor is lower than in rheumatoid arthritis).