Lupus anticoagulant .Antiphospholipid syndrome .- Causes, Symptoms and Treatment .MF .
Lupus anticoagulant (LA) - immunoglobulin class IgG.Lupus anticoagulant - antiphospholipid antibody, blood enzymes.Lupus anticoagulant got its name due to the fact that was first identified in the blood of patients with systemic lupus erythematosus.
doctor may suspect the presence of lupus anticoagulant in blood, if the extension of the activated partial thromboplastin time (APTT), which is typical of slowing blood clotting, bleeding occurs and there is a risk of thrombosis.
Norma lupus anticoagulant in blood: 0.8-1.2 cond.u
Lupus anticoagulant and other antibodies to phospholipids - one of the main features of antiphospholipid syn
lupus anticoagulant, increasing in amount in the blood, are attached to the walls of blood vessels, platelets, react clotting, causing thrombosis.
Depending on the size of the thrombus, the degree of destruction of the vessel location, vessel closure rate of antiphospholipid syndrome may be different to show.The most common symptom of antiphospholipid syndrome - livedo reticularis - a fine mesh of vessels on the skin surface, which becomes visible in the cold is better.Symptoms may be even ulceration and necrosis of the skin of the fingers or toes.
small vascular lesions in APS cause lung organ dysfunction, a large loss is chronic organ disease (liver cirrhosis, Alzheimer's disease).Blood clots cause pulmonary thromboembolism.Antiphospholipid syndrome - one of the major causes of myocardial infarction in young people up to 40 years.
Increased lupus anticoagulant in the blood can be a sign of the following diseases:
autoimmune disease systemic lupus erythematosus
thrombosis after ischemic cerebrovascular disorder.
in pregnant women increase lupus anticoagulant in the blood can trigger the development of thrombosis, placental arteries, which can cause fetal death, miscarriage and premature birth.
Lupus anticoagulant in the blood may rise as a complication of drug therapy, and as a result of taking certain medications.
definition of lupus anticoagulant does not give sufficient reasons for the setting of a physician diagnosis.BA level may be affected by various factors.The discovery of a large number of lupus anticoagulant in blood will indicate the need for further investigation.